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Naringenin
API na Halitta
Naringenin.jpg
innabi.jpg

Naringenin

Naringenin (CAS: 67604-48-2) dihydroflavonoid ne na halitta da kuma nau'in aglycone na naringin. A matsayin babban sinadarin bioactive a cikin 'ya'yan itatuwa citrus (misali, innabi, lemu), yana nuna fa'idodi masu yawa na magunguna, musamman a cikin matsalolin metabolism, tasirin hana kumburi, da kuma kare jijiyoyi.

Sunan Samfurin: Naringenin

Sunan IUPAC: (2S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-daya

Lambar CAS: 67604-48-2

Tsarin Kwayoyin Halitta: C₁₅H₁₂O₅

    Tuntube mu
    cikakkun bayanai game da samfurin
    bayanin samfurin

    bayanin1

    bayanin2

    Naringenin

    Bayanan asali

    Sunan Samfurin: Naringenin

    Sunan IUPAC: (2S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-daya

    Lambar CAS: 67604-48-2

    Tsarin Kwayoyin Halitta: C₁₅H₁₂O₅

    Kayayyakin Sinadaran Halitta:

    Sigogi

    Daraja/Bayani

    Bayyana

    Foda mai launin rawaya mai haske

    Wurin Narkewa

    251-253°C

    Narkewa

    Rashin ruwa sosai (0.01 mg/mL), mai narkewa a cikin DMSO2/ethanol

    logP

    2.1 (matsakaicin lipophilicity)

    pKa

    7.1 (phenolic OH), 9.5 (enolic OH)

    Ma'aunin Inganci: CP2020,JP, Abokin Ciniki An Yi

    Ƙayyadewa

    Abubuwan Gwaji

    Daidaitacce

    Naringenin (CAS: 67604-48-2)

    Kashi 98% ta hanyar HPLC

    Asara idan aka busar da ita

    ≤5.0%

    Ragowar wuta

    ≤2.0%

    Mahimman Sifofi

    index_10-7

    Tushen Halitta

    'Ya'yan itacen Citrus (mafi yawan innabi), tumatir, da ganye (misali, Scutellaria baicalensis).
    index_10-7

    Mai aiki da yawa

    Yana haɗa antioxidant, anti-inflammatory, metabolism regulatory, da antifibrotic Properties.
    index_10-7

    Babban Ayyukan Halittu

    Yana da sauƙin sha kuma yana da takamaiman manufa idan aka kwatanta da sifar glycoside (naringin).

    Tsarin Magunguna

    1. Cibiyar Sadarwar Molecular

    Cibiyar Sadarwar Molecular

    2. Magungunan Magunguna

    Sha

    Bioavailability na baki 15-20% (ƙirƙirar liposomal ta ƙaru zuwa 50%).

    Rarrabawa

    Yadu sosai a cikin hanta, koda, da kwakwalwa (shigar BBB ~ 5%).

    Metabolism

    Glucuronidation na hanta (UGT1A1/1A9), hydroxylation (CYP2C9/2C19).

    Najasa

    Mafi yawan kamuwa da cutar biliary (70%), fitar fitsari ƙasa da 10%.

    Aikace-aikacen Asibiti

    Nuni

    Tsarin aiki

    Mataki na Clinical;

    Ciwon suga na Type 2

    Inganta IR + yana hana shan glucose

    Gwaje-gwajen Mataki na II

    NAFLD

    Metabolism na lipid + tasirin antifibrotic

    Gwaje-gwajen Mataki na I

    Ciwon Menopausal

    Zaɓaɓɓen ERβ agonism

    Kafin a fara aikin asibiti

    Yawan Sha da Gudanarwa

    index_10-7

    Matsalolin Narkewar Abinci

    100-300 MG/rana (ana raba allurai).
    index_10-7

    Ƙarin Maganin Kariya daga Cututtuka

    50-100 MG/rana.
    index_10-7

    Matsakaicin Yawan da Aka Yi Haƙuri da Shi

    ≤500 MG magani ɗaya (manya masu lafiya).

    Kimanta Tsaro

    1. Illolin da ke tattare da hakan

    Tsarin

    Lamarin

    Bayyanannu;

    Na ciki

    10%

    Gudawa mai sauƙi

    Endocrine

    Tasirin Estrogenic

    Rashin ji sosai

    Ba kasafai ake samu ba

    Kuraje

    2. Hulɗar Magani​

    Substrates na CYP3A4​ (misali, simvastatin): AUC na iya ninkawa.

    Magungunan hana zubar jini​ (warfarin): Yana tsawaita PT/INR (ana buƙatar sa ido).

    Ci gaban Bincike Kore mafi girma

    Sabbin Ka'idoji
    Nanoemulsions: 80% bioavailability (bayanan dabbobi).
    Alamun Transdermal: Don amfani da maganin kumburi na gida (misali, arthritis).

    Sabbin Alamomi
    COVID-19: Yana hana 3CL protease (IC₅₀=25 μM).
    Cutar Parkinson: Yana kunna hanyar Parkin/PINK1 (samfurin ƙwayoyin halitta).

    pomelo

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    Kamar samfurin Farashi, Takamaiman Bayani, MOA, MSDS, Jadawalin Gudawa, Cikakkun bayanai game da shiryawa, Lokacin Jigilar Kaya, Lokacin Biyan Kuɗi, sabis bayan Siyarwa da sauransu.

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